It doesn't look like this is currently possible, but it would be nice! It would be great to be able to assign a learnable to "All Learners" minus one or two groups, rather than trying to create a group that includes everyone minus a department. I imagine something behind the scenes would make that complicated, but it would be great if a 'relevance' option was "exclude." So if someone is in more than one group, the default would be to exclude them if they're in that group. The best use case I can think of is "All Learners" minus executives. It's certainly possible to create a smart group that would do that too, but thought I'd suggest this as a feature in light of what LoriAnn suggested.